Drug Guide: Atropine

pillsPronounced

(a’troe-peen)

Absorption

Well absorbed (PO, SUBCUT, IM)

Distribution

Crosses blood-brain barrier, placenta

Metabolism

Liver

Excretion

Kidneys, unchanged (70%-90%); breast milk

Half-life

13-40 hr

Action

Blocks acetylcholine at parasympathetic neuroeffector sites; increases cardiac output, heart rate by blocking vagal simulation in heart; dries secretions by blocking vagus.

Therapeutic Outcome

Drying of secretions, increased heart rate, cycloplegia, mydriasis.

Uses

Bradycardia <40-50 bpm, bradydysrhythmia, reversal of anti cholinesterase agents, insecticide poisoning, blocking cardiac vagal reflexes, decreasing secretions before surgery, antipasmodic with GU and biliary surgery, bronchodilator.

Contraindications

Hypersensitivity to belladonna alkaloids, closed-angle glaucoma, GI obstructions, myasthenia gravis, thyrotoxicosis, ulcerative colitis, prostatic hypertrophy, tachycardia/tachydysrhythmias, asthma, acute hemorrhage, severe hepatic disease, myocardial ischemia.

 

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